Kenya is one of only two countries where children died
during the trial of a sickle cell drug called voxelotor; new data released by
the manufacturer has revealed.
The drug, sold under the brand name Oxbryta, was pulled from
every market globally in September 2024, after more children died while taking
it in the trial than while taking a placebo pill.
Investigators said the drug did not directly cause the
deaths.
A newly released full scientific paper on the trial, called
HOPE Kids 2, reveals that eight children taking the drug died in Kenya and
Nigeria.
The study took place at 21 hospitals in eight countries
between November 2020 and January 2023.
Doctors were testing whether voxelotor could protect
children with sickle cell disease (SCD) from having a stroke. Children with SCD
have a significantly higher risk of having a stroke.
The results indicate the drug actually worked and lowered
children’s stroke risk.
The danger was the unexplained deaths and also increased
severe pain crises in patients who received the drug compared to those who
received the placebo.
“Our primary concern
is for patients who suffer from SCD, which remains a very serious and
difficult-to-treat disease with limited treatment options,” said Aida
Habtezion, chief medical officer and head of worldwide medical and safety at
Pfizer, when the company withdrew the drug in 2024.
The full results, which the investigators have published in
the American Journal of Haematology, show they tested the drug on 236 children
with sickle cell in the eight countries.
Half received the drug, half received a placebo, for close
to two years. Eight children died in the voxelotor group compared to two in the
placebo group.
Doctors running the trial did not blame the drug for the
deaths, saying each death was linked to known dangers like malaria or the
sickle cell disease itself.
Even so, the imbalance was severe enough to trigger the 2024
withdrawal, and it is only in this newly published data that the full
geographic pattern has come to light.
“FDA understands the importance of having safe and effective
medications available to improve the health of patients living with this rare,
serious disease,” the US Food and Drug Administration said.
Voxelotor was never sold commercially in Kenyan pharmacies.
It was not listed as registered for sale by the Pharmacy and Poisons Board
(PPB), the government body that approves which medicines can be sold in the
country.
The trial in Kenya was run partly through the Kenya Medical
Research Institute (Kemri) and the University of Nairobi.
The failed drug shows the struggle SCD patients face in
getting a drug that actually works for them.
The standard treatment for most patients remains a much
older and cheaper drug called hydroxyurea.
Kenya carries one of the heaviest sickle cell burdens in the
region. Dr Gladwell Gathecha, acting head of the Division of Non-Communicable
Diseases at the Ministry of Health, said Kenya has 250,000 people living with
sickle cell.
“Each year we have around 14,000 infants who are born
with sickle cell, and sadly we lose around 400 people, or 400 warriors, every
year,” she said.
“Out of the 47 counties in Kenya, 17 are considered
highly vulnerable for sickle cell, mostly around western Kenya, Lake Victoria
and the coast.”
Dr Gathecha also revealed that access to even the basic,
approved drug remains patchy.
She said a recent
check of the health information system found that among high-burden patients,
only about a third of facilities had hydroxyurea in stock in June, and that the
ministry is now working with manufacturers and county governments to bring the
price and supply problem under control.
She spoke at the
ongoing third global sickle cell disease conference in Nairobi.
Health Cabinet Secretary Aden Duale, speaking at the same
forum, said the Social Health Authority now pays for outpatient care,
transfusions and specialised procedures for sickle cell patients.
He said the ministry is building a live national digital
registry within the next two months so every patient’s status and needs can be
tracked.
“A child’s access to early diagnosis and quality care
must not depend on the birthplace of the family, or the income of that
family,” he said.
