Ghana will be without the services of the Ayew brothers for the international friendly with Chile on Wednesday.
The Marseille duo are deemed injured after their weekend loss to Brest.
Their French club according to sources have officially notified the Ghana FA of their decision not to release Andre and Jordan Ayew for the game being played in Philadelphia.
Only sixteen players can now be relied upon by coach Goran Stevanovic who was issued a traveling visa Monday afternoon to join his team in the USA.
The Black Stars will be looking to ease the pain of Ghanaians following their disappointing fourth-place finish at the 2012 Africa Cup of Nations with a win over the South Americans.