Midfielders Tomas Rosicky and Yossi Benayoun both return to the starting line-up as Arsene Wenger makes four changes to the side which won at Aston Villa.
Israel international Benayoun makes his first Premier League start of the season, and joins Rosicky and Mikel Arteta in a three-man midfield.
Johan Djourou and Alex Song also start for the Gunners, as Theo Walcott, Aaron Ramsey, Emmanuel Frimpong and Francis Coquelin all miss out.
Meanwhile, Robin van Persie starts up front as he looks for two more goals to equal Alan Shearer’s record for Premier League strikes in a calendar year.
Wolves make just the one change to the side which drew 2-2 with Norwich City last time out, as Anthony Forde comes in for Sylvan Ebanks-Blake to form a five-man midfield for the visitors.
Striker Kevin Doyle, who has been linked with a move to Arsenal in the past, has to settle for a place on the bench as Steven Fletcher leads the line for Mick McCarthy’s men.
Arsenal: Szczesny; Djourou, Koscielny, Mertesacker, Vermaelen; Song, Arteta, Rosicky; Benayoun, Gervinho, Van Persie.
Subs: Almunia, Miquel, Coquelin, Ramsey, Arshavin, Oxlade-Chamberlain, Chamakh.
Wolves: Hennessey; Zubar, Berra, Johnson, Ward; Forde, Henry, Milijas, Jarvis; Hunt; Fletcher.
Subs: De Vries, Elokobi, Stearman, Hammill, Guedioura, Doyle, Ebanks-Blake.