The 23-year-old had been without a club after terminating his contract with Portuguese outfit by mutual consent earlier in the summer.
The former Braga man flew to London on Wednesday to pass a medical with Fulham and put pen-to-paper on a three-year contract which will keep him at Craven Cottage until 2014.
“I am happy to have completed my transfer to Fulham and the Premier League today,” Sa told the club’s official website.
“This is an enormous opportunity for me and I’m looking forward to joining the team and entering the next phase of my development.
“It’s a wonderful challenge for me and I am keen to bring my qualities to Fulham and the Premier League.”
Sa joined Porto from Braga in the summer of 2009, but failed to an impact at the Estadio do Dragao. he then spent the last season on loan at CD Nacional, and now joins Fulham on a Bosman transfer.
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Official: Fulham sign former Porto striker Orlando Sa on a free transfer