Saracens bring in scrum-half Richard Wigglesworth and back row Kelly Brown for the injured Neil de Kock and Justin Melck respectively.
Prop Matt Stevens and lock Steve Borthwick are included to face their former club and Jacques Burger is back on the bench after six weeks out.
Bath make three changes to the side that lost 37-6 to Leicester last week.
Lock Peter Short makes his first appearance since November, replacing Danny Grewcock.
In the backs Shontayne Hape comes in for Sam Vesty at centre and Matt Carraro replaces Tom Biggs on the wing.
Bath defence and skills coach Brad Davis told BBC Points West:
“We know they’re a tough team to crack, they’re good defensively and in our situation we’re looking at it as a must-win match for us.
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Bath’s Davis wary of Stevens threat
“From a coach that’s worked with him (Matt Stevens) for two or three years I’m just glad he’s back on the field doing what he does best.
“He’s a dynamic ball carrier and one of the best props in the business when he’s got the ball in hand but we’ve got plan that will hopefully curtail that.”
Saracens: Goode; Strettle, Wyles, Barritt, Short; Farrell, Wigglesworth; Stevens, Brits, Nieto; Borthwick (capt), Smith; Brown, Saull, Joubert.
Replacements: George, Gill, du Plessis, Botha, Burger, Barrett, Powell, Cato.
Bath: Abendanon, Banahan, Williams, Hape, Carraro, James, Claassens, Flatman, Mears, Bell, Hooper, Short, Skirving, Watson (capt), Taylor.
Replacements: Dixon, Catt, Wilson, Fernandez Lobbe, Mercer, McMillan, Vesty, Cuthbert
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Saracens v Bath (Sun)