Harlequins, still buoyant after last week’s demoltion of Gloucester, will be boosted by the return of Nick Evans.
The former All Black reclaims the fly-half berth from Rory Clegg, who drops to the bench, in the only change to the starting line-up.
Leicester make just one change to the side that recorded a record win over Bath at the Rec last weekend.
Jordan Crane comes in at number eight, in his first start since January, in place of Thomas Waldrom.
Harlequins: Brown; Camacho, Lowe, Turner-Hall, Monye; Evans, Care; Marler, Gray, Andress; Kohn, Robson; Fa’asavalu, Robshaw (capt), Easter.
Replacements: Cairns, Jones, Lambert, Vallejos, Skinner, Moore, Clegg, Williams.
Leicester: Hamilton; Agulla, M Tuilagi, Allen, A Tuilagi; Flood, Youngs; Ayerza, Chuter, Cole; Mafi, Slater; Croft, Newby (capt), Crane.
Replacements: Hawkins, Stankovich, Castrogiovanni, Skivington, Waldrom, Grindal, Staunton, Smith.
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Harlequins v Leicester (Sat)