Ivory Coast international Toure joined Man City from Arsenal in 2009
Manchester City defender Kolo Toure has been suspended after testing positive for a specified substance.
The 29-year-old was informed by the Football Association that an A sample he provided had returned positive.
City confirmed in a statement that Toure had been suspended “pending the outcome of the legal process”.
Ivory Coast international Toure, whose brother Yaya also plays for City, is a former club captain who joined City from Arsenal in July 2009.
The City statement added: “There will be no further comment from the football club at this stage.”
The World Anti-Doping Agency defines a specified substance as one that is “more susceptible to a credible, non-doping explanation”.
The Wada punishment for such a positive test ranges from a warning to a two-year ban.
Toure was the skipper of City until the start of the current campaign, when the armband was passed to Carlos Tevez.
The Ivorian defender was brought to the Premier League by Arsenal in 2002 and he remained with the London club until his £14m transfer to City.
Toure, who is under contract with City until the summer of 2013, was one of several high-profile arrivals in the summer of 2009 as then-manager Mark Hughes spent more than £100m on new players.
He has gone on to make more than 50 appearances for City, although he was rested for Wednesday’s FA Cup victory over Aston Villa.
City will play Reading in the quarter-final of the FA Cup, are set to take on Dynamo Kiev in the Europa League and lie third in the Premier League, 10 points behind leaders Manchester United.
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City’s Kolo Toure fails drug test