Marshall, 23, sustained a head injury in Ireland’s first win on Argentine soil, a 29-17 victory in Resistencia.
The Ulster centre will be assessed before the second game, but Ireland are likely to rest him as a precaution.
In good news for the Six Nations champions, fly-half Jonny Sexton has recovered from knee cramp and is likely to take his place.
Sexton contributed 13 points for Ireland in their series-opening win at the Estadio Centenario, including crossing for a second-half try.
Despite their victory, Ireland are desperate to improve their defence having conceded two tries to the hosts.
“I’m disappointed and (assistant coach) Les (Kiss) will be disappointed as well, with the missed tackles,” captain Paul O’Connell said after the win.
“I think Argentina have a lot of very talented footballers with excellent footwork, and size as well.
“Certainly the way they put pressure on you off turnovers, they love hitting you off turnovers.
“That bit of play when we nearly scored a try early in the first half, they take a quick tap and they nearly score 30 seconds later – that kind of thing is probably something we’ve spoken about every day since we came together, and that was frustrating for that to happen.
“We missed tackles, tackles that I think we should have made, and it conceded momentum to Argentina.
“We need to defend better if we’re going to put in a better performance against them next Saturday.”
If they manage to cut out their errors from the opener, Ireland should be far more comfortable in the second and final Test of the series.
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