As has been the case since their Euro 2016 win, Fernando Santos’ side haven’t proven convincing and were even somewhat fortunate to come through the Ghana game with three points.
Uruguay, meanwhile, were hardly the most progressive during their draw with South Korea but certainly have the quality in attack capable of hurting Portugal.
Here’s everything you need to know.
Date, kick-off time and venue
The World Cup group stage game is scheduled for a 7pm GMT kick-off time on Monday November 28, 2022.
The Lusail Iconic Stadium in Lusail will host.
Where to watch Portugal vs Uruguay
TV channel: The game will be broadcast on ITV 1 and STV.
Live stream: ITVX and STV Player (both free with a subscription) will offer live streams.
LIVE coverage: Follow all of the action with Standard Sport’s match blog.
Portugal vs Uruguay team news
Portugal are ready to unleash 39-year-old Pepe against Uruguay.
Head coach Fernando Santos described Pepe as a “monster” ahead of the Group F clash and he is set for an intriguing head-to-head battle with Luis Suarez.
Portugal are expected to be without Danilo Pereira for the rest of the World Cup after the Paris Saint-Germain start fractured his ribs in training this week.
That has opened the door for Pepe, who at 39 years and 275 days old will become the oldest player to play in a World Cup game for Portugal.
Uruguay are again set to be without centre-back Ronald Araujo, who underwent thigh surgery in September and is not expected to be fit.
Portugal vs Uruguay prediction
With neither side particularly free flowing, it’s hard to imagine the most exciting of games.
Still, Portugal have more dynamic options in attack, capable of moments of magic.
Portugal to win 1-0.
Head to head (h2h) history and results
Portugal wins: 1
Uruguay wins: 1
Portugal vs Uruguay latest odds
Portugal to win: 10/11
Uruguay to win: 29/10
Odds via BetVictor and subject to change.