The combustible Italian was shown a third yellow card of the season by referee Simon Hooper during Sunday’s 4-1 Premier League win over Crystal Palace.
De Zerbi felt Palace debutant Daniel Munoz handled as he attempted to prevent a Brighton attack after just seven minutes and was booked for his reaction.
But the 44-year-old believes his squad will not be affected by his absence from the dugout.
The Seagulls boss said: “The yellow card was right. I forgot that with another yellow card I can’t be on the bench at Tottenham — but my players can play without their coach there.”
Goals from Lewis Dunk — after just two minutes — Jack Hinshelwood and Facundo Buonanotte put Brighton 3-0 up at half-time.
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