The midfielder is suspended after picking up his second yellow card of the tournament during the win over Burnley last month, leaving manager Erik ten Hag fairly light in attacking areas.
While Fernandes’ absence could well have handed Donny van de Beek another chance to impress, the club have confirmed the Dutchman is unlikely to feature following his injury against Bournemouth.
Elsewhere, Lisandro Martinez is pushing for his first start since winning the World Cup with Argentina and Harry Maguire could join him in central defence.
Jadon Sancho, however, is not thought to be ready to feature and Ten Hag has confirmed Anthony Martial is not yet ready to start week in, week out.
New signing Jack Butland may be handed his debut.
Predicted Manchester United XI (4-2-3-1): Butland; Wan-Bissaka, Maguire, Martinez, Malacia; McTominay, Fred; Elanga, Eriksen, Antony; Garnacho.
Doubts: Van de Beek
Suspended: Fernandes
Date and time: 8pm GMT, January 10 2023
));/**/