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A man with terminal heart disease is responding well three days after being given a genetically modified pig heart in a first-of-its-kind surgery, his doctors reported on Monday.
The surgery, performed by a team at the University of Maryland Medicine in the United States, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene-editing tools.<\/p>\n
If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.<\/p>\n
\u201cThis was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,\u201d Dr Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.<\/p>\n
\u201cWe are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,\u201d Griffith added.<\/p>\n
For David Bennett, a 57-year-old from Maryland, the heart transplant was his last option.<\/p>\n
\u201cIt was either die or do this transplant. I want to live. I know it\u2019s a shot in the dark, but it\u2019s my last choice,\u201d Bennett said a day before his surgery, according to a statement released by the university.<\/p>\n
To move ahead with the experimental surgery, the university obtained emergency authorisation from the US Food and Drug Administration on New Year\u2019s Eve through its compassionate use programme.<\/p>\n
\u201cThe FDA used our data and data on the experimental pig to authorise the transplant in an end-stage heart disease patient who had no other treatment options,\u201d said Dr Muhammad Mohiuddin, who heads the University\u2019s programme on xenotransplantation \u2013 transplanting animal organs into humans.
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About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to organdonor.gov.<\/p>\n
Bennett\u2019s genetically modified pig heart was provided by Revivicor, a regenerative medicine company based in Virginia. On the morning of the surgery, the transplant team removed the pig\u2019s heart and placed it into a special device to preserve its function until the surgery.<\/p>\n
Pigs have long been a tantalising source of potential transplants because their organs are so similar to humans.<\/p>\n
Other organs from pigs being researched for transplantation into humans include kidneys, liver and lungs.<\/p>\n
Prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.<\/p>\n
Scientists have tackled that problem by editing away potentially harmful genes.<\/p>\n
In the heart implanted in Bennett, three genes previously linked with organ rejection were \u201cknocked out\u201d of the donor pig, and six human genes linked with immune acceptance were inserted into the pig genome.
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Researchers also deleted a pig gene to prevent excessive growth of the pig heart tissue.<\/p>\n
The work was funded in part with a $15.7 million research grant to evaluate Revivicor\u2019s genetically-modified pig hearts in baboon studies.<\/p>\n
In addition to the genetic changes to the pig heart, Bennett received an experimental anti-rejection drug.<\/p>\n
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