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By Lihle Sosibo<\/em><\/p>\n Newly capped Dr Vuyolwethu Mxinwa hopes that his research findings will further inform new treatment strategies aimed at preventing cardiovascular complications associated with obesity and type 2 diabetes.<\/p>\n The researcher\u2019s study resulted in him being awarded a Doctor of Philosophy degree in Health Sciences (Physiology) from the University of KwaZulu-Natal (UKZN) during the university\u2019s recent Spring Graduation.<\/p>\n Mxinwa\u2019s study sought to understand the inter-relationship between the immune and metabolic systems, with a special focus on diet-induced obesity, metabolic syndrome and related cardiovascular complications.<\/p>\n His PhD research work showed that a high fat diet alters the metabolic system and the body\u2019s ability to breakdown fats and glucose, leading to an increase in blood glucose insulin and cholesterol levels.<\/p>\n The study also revealed that the changes in glucose and cholesterol levels alter certain types of innate lymphoid cells as well as the proteins (referred to as cytokines) that these cells release in the blood.<\/p>\n Additionally, Mxinwa\u2019s work illustrated that taking the lipid-lowering drug fluvastatin and the glucose-lowering drug metformin reduced the inflammation associated with specific innate lymphoid cells and improved blood glucose levels.<\/p>\n \u2018Huge accomplishment\u2019<\/strong><\/p>\n Mxinwa grew up in Lusikisiki in the Eastern Cape, completing his matric at Siwali High \u2013 a rural school that had no science or computer laboratories at the time. His first encounter with computers was at UKZN.<\/p>\n \u201cMy PhD is a huge accomplishment, not just for me and my family, but also for the community I come from,\u201d said the proud 30-year-old.<\/p>\n \u2018To my knowledge, I am the first person from my high school to obtain a PhD. I hope and believe I will not be the last, as my academic success should encourage more people from my community to enrol for postgraduate studies when there is an opportunity.\u201d<\/p>\n Mxinwa enrolled at UKZN in 2018 and in 2020 was appointed as a lecturer in the Discipline of Human Physiology at the School of Laboratory Medicine and Medical Sciences. He is still actively involved in undergraduate teaching and supervising MSc and Honours research students.<\/p>\n During the course of his PhD journey he authored and co-authored more than 20 publications and a book chapter.<\/p>\n He was recently awarded the Research Equipment Grant of R561 125 under the category of emerging researchers.<\/p>\n \u201cMy experience as a student at UKZN was great. I made friends and connections who have contributed greatly to my growth as a researcher and as a human being,\u201d said Mxinwa.<\/p>\n