Three outstanding fixtures in the First Capital Plus Premier League will be cleared on Sunday with Asante Kotoko seeking to open a 10-point gap.
The match-day-16 fixtures will kick off at 15:00GMT with all six sides eying all the spoils.
Out of the CAF Champions League, Kotoko will continue with their bid for a successful title defence when they take on second from bottom, Ebusua Dwarfs at the Baba Yara Stadium.
Following their impressive win against Medeama, the Porcupine Warriors will be hoping to enjoy some home comfort and put behind them their continental blues.
Dwarfs, in the bottom ranks of the table will need to pick up valuable points to keep their survival chase on track.
Berekum Chelsea begin their quest to play themselves out of the relegation zone in the Premier League with a home game against AshantiGold on Sunday.
With two games in hand in the Premier League and beginning with the visit of the Miners to the Golden City Park, rock-bottom Chelsea will need to win to lift themselves to safety and replicate their progress in the continental club campaign in the domestic competition.
At the Tema Stadium, bottom side, Inter Allies are not confirmed relegation candidates just yet as they can secure another season in the top-flight depending on how they perform against Medeama.
Medeama, who lost to Kotoko on Thursday at home will take the trip to Tema with the hope of keeping their season going as they remain 15 points adrift the summit.