The Porcupine Warriors have to see off the second-tier side to keep their treble chase intact this season as holders Medeama battle Okwawu United in the Cup competition.
Ghana champions Asante Kotoko have drawn second-tier side Istanbul in the last 16 of the MTN FA Cup.
The Porcupine Warriors will host the minnows in Kumasi as title holders Medeama head to Nkawkaw to face Okwawu United.
Former champions New Edubiase square off with Feyenoord in Gomoa. The fourth round matches of the Cup competition will be played between February 20 and 23.
Round of 16 Pairings
Asante Kotoko vs Istanbul – Baba Yara
Berekum Chelsea vs Inter Allies – Golden City
Hasaacas vs Gold Stars – Essipong
Feyenoord vs New Edubiase – Gomoa
AshantiGold vs Mighty Jets – Len Clay
Rosepack/Right to dream/Ho Dynamos/King Faisal vs Metro Stars
Okwawu United vs Medeama – Nkawkaw
Aduana/Asokwa Deportivo/Dunkwa United/Dawenhya/Royal Faith/Bazooka vs Bechem United