{"id":365076,"date":"2011-04-04T05:25:46","date_gmt":"2011-04-04T05:25:46","guid":{"rendered":"http:\/\/www.ghanamma.net\/2011\/04\/04\/scientists-find-new-alzheimer%e2%80%99s-risk-genes\/"},"modified":"2011-04-04T05:25:46","modified_gmt":"2011-04-04T05:25:46","slug":"scientists-find-new-alzheimers-risk-genes","status":"publish","type":"post","link":"https:\/\/www.ghanamma.com\/2011\/04\/04\/scientists-find-new-alzheimers-risk-genes\/","title":{"rendered":"Scientists find new Alzheimer\u2019s risk genes"},"content":{"rendered":"
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You Are Here: Home<\/a> \u00bb Africa\/International<\/a> \u00bb Scientists find new Alzheimer\u2019s risk genes<\/p>\n

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\t\t\t \tPage last updated at Monday, April 4, 2011 5:05 AM \/\/ <\/span>\n\t\t\t <\/div>\n

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\"\"<\/a>Scientists looking for the genetic triggers that lead to Alzheimer\u2019s have identified five more, doubling the number linked with the mind-wasting disease.<\/p>\n

If drugs or lifestyle changes could be devised to counter these genetic variations, more than 60 percent of Alzheimer\u2019s cases could be prevented, according to the researchers, whose work was published in the journal Nature Genetics on Sunday.<\/p>\n

But those discoveries could be at least 15 years away, they said.<\/p>\n

Alzheimer\u2019s is the most common form of dementia, a fatal brain disease that affects memory, thinking, behavior and the ability to handle daily activities. It is increasingly placing a heavy burden on societies and economies across the world.<\/p>\n

\u201cWe are beginning to piece together the jigsaw and gain new understanding,\u201d said Julie Williams from Cardiff University\u2019s center for neuropsychiatric genetics and genomics, who led the study.<\/p>\n

\u201cIf we were able to remove the detrimental effects of these genes through treatments, we hope we can help reduce the proportion of people developing Alzheimer\u2019s in the long-term.\u201d<\/p>\n

The researchers said the genetic variants they found highlight specific differences in people who get Alzheimer\u2019s, including variations in the immune system, the ways the brain handles cholesterol and lipids as well as a process called endocytosis which removes toxic protein from the brain.<\/p>\n

BIG BURDEN<\/p>\n

Alzheimer\u2019s Disease International predicts that as populations age, dementia cases will almost double every 20 years to around 66 million in 2030 and 115 million in 2050, with much of that rise happening in poorer nations.<\/p>\n

\u201cWhat\u2019s exciting is the genes we now know of \u2014 the five new ones, plus those previously identified \u2014 are clustering in patterns,\u201d Williams said at a briefing in London.<\/p>\n

Scientists suspect genes can explain 60 to 80 percent of the risk of late onset Alzheimer\u2019s, the kind that occurs with age.<\/p>\n

To find these new gene variants, Williams and an international consortium of fellow researchers looked at data from 25,000 people with Alzheimer\u2019s disease and 45,000 healthy people who were used as \u201ccontrols.\u201d<\/p>\n

They found that common gene variants called ABCA7, EPHA1, CD33 and CD2AP and MS42A were linked with an increased risk of developing the disease. \u201cThese five genes now show compelling evidence of association with Alzheimer\u2019s disease,\u201d she said.<\/p>\n

Previous studies over the past few decades have established that gene variants known as CLU, PICALM, CRI, BIN1 and APOE are also linked to Alzheimer\u2019s risk.
Source: Reuters<\/p>\n

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