A 50-seater passenger plane has crashed into a house in Buffalo, New York State, officials have said.
CNN cited aviation officials saying 48 people were on board the Newark to Buffalo flight.
The Associated Press news agency quoted fire officials as saying there were no survivors, though it said it was not clear how many people were on board.
The plane hit a house at 2210 (0310GMT), officials said. TV footage showed the house engulfed in flames.
Two people not on the plane were taken to hospital with minor injuries, CNN said.
Continental Express flight 3407, operated by Colgan Air, had reportedly been delayed, and was approaching the airport in Buffalo two hours later than scheduled.
The Bombardier Dash 8 Q400 came down about five miles (8km) from the airport.
Twelve houses near the crash site were evacuated, because of concerns about the fuel left on the crashed plane.