Champions Asante Kotoko can revitalize their league campaign with a win against newly-promoted Chelsea from Bechem at the Baba Yara Stadium.
Kotoko suffered a humiliating 2-1 defeat at the hands of another debutant Sporting Mirren last week and will like to get their campaign back on track.
Chelsea had their image dented after a 1-3 home loss to Real Tamale United and tasting a second defeat in a row is likely to be averted.
Hearts of Oak host Gamba All Blacks at the Ohene Djan Stadium in a tie that the victory pendulum is likely to swing to the home team.
Tema Youth want to apply the brakes on Sporting Mirren who recorded a famous 2-1 win over Kotoko last week at the Tema Stadium.
Eleven Wise welcome Liberty Professionals at the Essipong Stadium after sharing points with city-rivals Hasaacas.
Real Tamale United battle Wa All Stars at the Tamale Stadium and Kessben host King Faisal in an Ashanti Regional clash.
Arsenals can pick the maximum points at the Golden City Park against unimpressive AshantiGold.
Heart of Lions want to add bottom-placed Sekondi Hasaacas to their domestic victims at the Kpando Park.