Alex Bruce and Tom Huddlestone, who featured in the 4-0 win over Cardiff at the weekend, have dropped out with knocks.
Meanwhile, Brighton will start Leonardo Ulloa even though he has an ankle problem.
Hull team to face Brighton: Harper, Figueroa, Elmohamady, Chester, Davies, Meyler, Koren, Livermore, Aluko, Sagbo, Fryatt
Subs: McGregor, Rosenior, Bruce, Huddlestone, Boyd, Faye, Quinn
Brighton team to face Hull: Brezovan, Calderón, Ward, Andrews, Dunk, Upson, Ince, Forster-Caskey, Ulloa, Rodríguez Sánchez, D. López
Subs: Bruno, Greer, Chicksen, Ankergren, Obika, Lua Lua, March
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