Januzaj completed 80 minutes of United’s 2-0 win over Crystal Palace in the Premier League at the weekend, but he hasn’t even made the bench.
Robin van Persie and Wayne Rooney will start in just their second Champions League game together this season – with their other start coming in the 4-2 win over Bayer Leverkusen in which both were on the scoresheet.
Meanwhile, Ryan Giggs, who is just three appearances short of equalling the Champions League’s record appearance holder Raul (142), will start from the bench.
Olympiakos team to face Manchester United: Roberto, Leandro Salino, Manolas, Marcano, Holebas, Maniatis, Ndinga, Campbell, Dominguez, Perez, Olaitan
Subs: Megyeri, Paulo Machado, Samaris, Haedo Valdez, David Fuster, Papadopoulos, Bong Songo
Manchester United team to face Olympiakos: De Gea; Smalling, Ferdinand, Vidic, Evra; Valencia, Carrick, Cleverley, Young; Rooney, van Persie
Subs: Lindegaard, Büttner, Fellaini, Giggs, Kagawa, Hernandez, Welbeck
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