LeBron James and Chris Bosh combined for 50 points as the defending champions clinched the Eastern Conference finals 4-2 with a comprehensive win at American Airlines Arena in Miami.
James was restricted to just seven points in game five but he posted 25 points and six assists, while Heat team-mate Bosh had 25 points and eight rebounds to help the Miami franchise to a third straight play-offs win over the Pacers.
Rashard Lewis and Dwyane Wade produced solid contributions, finishing with 13 points respectively as the Heat kept their hopes of a third successive championship alive.
The Pacers, who avoided elimination courtesy of a three-point win in game five, were led by Paul George.
George scored a game-high 29 points to go with his eight boards but he had little help from the rest of the Indiana roster.
David West had 16 points, while Lance Stephenson (11 points) was the only other Pacers player to reach double figures.
Indiana were outscored by 26 points in the opening half, but salvaged some pride courtesy of a 34-26 final quarter in Miami.
The Heat will face the winner of the Western Conference series between the San Antonio Spurs and Oklahoma City Thunder.
Four-time champions San Antonio lead 3-2 ahead of game six on Saturday.
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