The German set up his commanding lead at Pinehurst with consecutive rounds of five-under 65 and he remains in control despite a 72 on Saturday.
Kaymer said he needed to stay aggressive despite his advantage, but knows the tough course could mean his lead disappears quickly.
“At the end of the day, if you play a golf course like this, it can be gone very quickly,” he told a news conference.
“You could see it today. I made three bogeys for the first six holes. I didn’t hit many fairways today.
“The challenge will be to keep going tomorrow and not try to defend anything. If you try to defend you’re not free enough, you don’t swing as freely.
“And that will be the challenge so we will see how I react tomorrow and how the body feels and how I handle the situation.”
At eight under, Kaymer is five shots ahead of Americans Rickie Fowler and Erik Compton and just one of six players under the card.
He said his two-over 72 was a decent round.
“It’s still a good round. Two-over par isn’t as bad as it looks on the scorecard,” Kaymer said.
“Little bit of an up and down start, a couple of early bogeys and then the eagle that brought me back to level par. And then I putted off the green.
“A lot of things were happening today but I think I kept it together very well even though I didn’t hit as many great shots as yesterday and Thursday.
“Overall, it’s a decent round.”
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